0122 - ARBOVIRUS ANTIBODY PANEL, IFA, SERUM:
Serum is tested against antigens of St. Louis Encephalitis and Western Equine Encephalitis viruses. IgG titers of 16 suggest exposure, while the presence of IgM indicates recent infection. Incidence is seasonal from mid to late summer (April-November). See specific arbovirus for individual testing.
0290 - BARTONELLA HENSELAE AB, IgG, SERUM:
Bartonella henselae is considered a causative agent of cat scratch disease.
0143 - COCCIDIOIDES AB, CF, SERUM:
All serum titers 1:4 should be considered presumptive evidence of coccidioidomycosis. Titers exceeding 1:16 usually reflect disseminated disease. In general, the higher the titer, the more severe the disease, and changes in serial titers are also of prognostic value. A negative CF test does not, however, rule out the diagnosis. Patients with cavitary disease are only 70% positive, and with nodular diseases, only 30% positive.
0145 - COCCIDIOIDES AB, IgG AND IgM, SERUM EIA:
A negative result with both IgM and IgG indicates that antibody for C. immitis antigen is either absent, below the level of detection of the assay or the specimen was obtained too early in the response. A positive result with either IgM or IgG implies the presence of antibody to C. immitis antigens. An early acute phase patient may only present an IgM response, while the chronic or convalescent patient may only present an IgG response.
0147 - CROUP PROFILE: See individual assay for description.
Panel includes: Influenzae A and B Viral Antibody, CF; Parainfluenzae virus antibody (Types 1-3), CF and Respiratory Syncytial virus (RSV) Antibody, IFA.
0152 - CYTOMEGALOVIRUS (CMV) ANTIBODY, IgG AND IgM, IFA, SERUM:
Evidence of active or recent infection requires an IgM titer 10 and/or a four-fold change in IgG titer between the acute and convalescent specimens. These criteria are more easily met in primary infection, as compared with reactivated or repeated infections.
0160 - ENCEPHALITIS ANTIBODY PANEL, SERUM: See individual assay for description.
Panel includes: Cytomegalovirus (CMV) IgG and IgM, IFA; Measles (Rubeola) IgG and IgM antibody panel, IFA; Herpes Simples virus (HSV) IgG & IgM, IFA Antibody Panel, Arbovirus, IgG & IgM, IFA and Mumps IgG Antibody, IFA
0161 - ENTAMOEBA HISTOLYTICA ANTIBODIES, EIA:
Serological studies are helpful in the diagnosis of invasive intestinal and extra-intestinal amebiasis. Asymptomatic cyst passers usually have negative serologic tests. Eighty-five percent of patients with biopsy proven invasive intestinal amebiasis have a positive serology study, whereas 95-100% of patients with extra-intestinal amebiasis are positive. Values may remain elevated 6 to 18 months following invasive disease.
0165 - EPSTEIN-BARR VIRAL CAPSID ANTIGEN (VCA) IgG AND IgM ANTIBODY, IFA, SERUM:
Both IgG and IgM antibody levels are titered. A four-fold increase in VCA-IgG or a VCA-IgM titer is indicative of current infection.
0173 - EXANTHEMAS AND ENANTHEMAS ANTIBODY PANEL, SERUM: See individual assay for description.
Panel includes: Herpes Simplex Virus (HSV), EIA; Adenovirus antibody, IFA; Mycoplasma pneumoniae antibody, CF; Measles IgG and IgM Antibody Panel, IFA: Rubella IgG and IgM Antibody, ELISA and Varicella-Zoster Virus antibody, IFA.
0174 - FEBRILE AGGLUTININS PANEL, DIRECT SLIDE AGGLUTINATION, SERUM:
Panel includes: Brucella abortus, Proteus OX 19, Salmonella Type H Group a, b, and d, Salmonella Type O group D
0175 - FTA-ABS, IFA:
The FTA-ABS is a specific treponemal assay to detect antibody to T. pallidum. the FTA-ABS becomes reactive 4-6 weeks after infection. Unlike the nontreponemal test, once the FTA-ABS test becomes reactive it will remain reactive for many years. Since the reactivity found with the FTA-ABS does not indicate response to therapy, it is not suitable for monitoring treatment. The FTA-ABS test does not distinguish between syphilis and other treponematoses such as yaws, pinta and bejil.
0181 - HELICOBACTER PYLORI AB, IgG, EIA:
Gastric colonization of Helicobacter pylori has been implicated as a cofactor in the development of some cases of gastritis and peptic or duodenal ulcer. Gastroduodenal disease caused by H. pylori can be successfully treated with antimicrobial therapy. Eradication of H. pylori infection has been associated with decreasing IgG antibody levels to H. pylori. As IgG levels to H. pylori are encountered in a large percentage of adults, clinicians should be aware that age-related acquisition of H. pylori contributes to the age-related increase in incidence of H. pylori antibody. As a result this test is best used to rule out H. pylori infection when the antibody results are negative.
0198 - HISTOPLASMOSIS ANTIBODY (YEAST AND MYCELIAL PHASE), CF, SERUM:
CF titers 8 are considered presumptive evidence of histoplasmosis, with the probability of infection rising with the height of the titer. Positive titers are also seen, however, with fungal disease other than histoplasmosis. Changing titers are useful both in diagnosis and in following a course of treatment.
0206 - INFLUENZAE A AND B VIRAL ANTIBODY, CF, SERUM:
Single titers of 128 are suggestive of recent infection. Titers of 8 to 32 can also be indicative of recent infection since CF antibody levels persist for only a few months. a four-fold or greater change in titer between acute and convalescent specimens confirms the diagnosis.
0207 - INFLUENZAE SYNDROME PANEL, SERUM: See individual assay for description.
Panel includes: Adenovirus Antibody, CF; Influenzae A and B Viral antibody, CF; Mycoplasma pneumoniae antibody, EIA and Q Fever (Coxiella burnetti) antibody, CF.
0209 - LEGIONELLA PNEUMOPHILA AB, IFA, SERUM:
Serum specimens are titered by indirect immunofluorescence against serogroups 1-6 of Legionella pneumophila. The rise in titer between acute and convalescent phase must be to 256 to be considered as evidence of recent infection. A standing or single titer of 256 is considered presumptive evidence of infection at an undetermined time. Current data indicate that titers of 32 and 64 in the absence of detectable disease are common.
0215 - MEASLES (RUBEOLA) IgG AND IgM ANTIBODY PANEL, IFA SERUM:
The traditional serologic diagnosis of measles requires a significant rise in antibody titer between acute and convalescent phase sera. However, the diagnosis can also be supported by demonstrating the presence of IgM antibody in a single specimen. Correct interpretation of serologic data depends upon the proper timing of specimen collection in relation to rash onset. This timing is especially important for interpreting negative IgM results since IgM antibody peaks approximately 10 days after exposure and may be undetectable 30 days after rash onset. Asymptomatic reinfection can occur in persons who have previously developed antibodies, whether from vaccination or from natural disease. Symptomatic reinfections are rare. These reinfections have been accompanied by rises in measles antibody titers.
0218 - MENINGOENCEPHALITIS (ENCEPHALITIS) PANEL, SERUM: See individual assay for description.
Panel includes: Herpes Simplex Virus (HSV), IFA ; Mumps Antibody: EIA; St. Louis Encephalitis Virus Antibody, IFA and Western Equine Encephalitis Antibody, IFA.
0219 - MENINGOENCEPHALITIS (ENCEPHALITIS) PANEL, CSF: See individual assay for description.
Panel includes: Herpes Simplex Virus (HSV), IFA; Mumps Antibody: EIA; St. Louis Encephalitis Virus Antibody, IFA and Western Equine Encephalitis Antibody, IFA
0220 - MHA-TP, MICROHEMAGGLUTINATION ASSAY, SERUM:
The test consists of a microhemagglutination assay for antibodies to Treponema pallidum. Treponemal tests vary in their reactivities in early syphilis; the varied sensitivities of the treponemal tests in primary syphilis appear to be related to the time of serum collection after lesion development. In secondary and latent stages, treponemal tests are usually 100% reactive. The sensitivity declines somewhat in the late stage of syphilis. In approximately 86% of cases of syphilis, once the treponemal tests are reactive, they remain reactive for life. Treponemal tests are qualitative and are not recommended for monitoring reinfection or the efficacy of treatment. In congenital syphilis, all treponemal tests are reactive. Passively transferred treponemal antibodies should be catabolized and undetectable in the noninfected infant by the age of 8 to 12 months. Although rare, false-positive results may occur in any of the treponemal tests during pregnancy; however, the MHA-TP test appears to be more specific than the FTA-ABS tests in this condition.
0235 - PARAINFLUENZA VIRUS ANTIBODY (TYPES 1-3), CF, SERUM:
Serological diagnosis of parainfluenza infection requires a four-fold or greater increase between acute and convalescent phase antibody titers. Most adults and children older than 6 months will show titer changes of this magnitude. Single titers 128 or stable high titers are generally related to recent infection. After initial infection, antibody responses at a later date are often heterotypic and include reaction to other paramyxoviruses (mumps). In the infant population less than 6 months of age, a combination of viral isolation and antigen detection methods is recommended.
0245 - RESPIRATORY VIRAL INFECTION, ADULT PANEL, SERUM: See individual assay for description.
Panel includes: Adenovirus antibody, CF; Q Fever (Coxiella burnetti) Antibody, CF; Influenzae A and B Viral Antibody, CF and Mycoplasma pneumoniae antibody, EIA.
0246 - RESPIRATORY VIRAL INFECTION, INFANT/CHILD PANEL, SERUM: See individual assay for description.
Panel includes: Adenovirus antibody, CF; Q Fever (Coxiella burnetti) Antibody, CF; Influenzae A and B Viral Antibody, CF; Mycoplasma pneumoniae antibody, EIA. Parainfluenza Virus antibody (Types 1-3), CF and Respiratory Syncytial Virus (RSV) IFA.
0247 - RESPIRATORY VIRAL INFECTION, NEWBORN PANEL, SERUM: See individual assay for description.
Panel includes: Cytomegalovirus IgG and IgM Antibody Panel, IFA; Herpes simplex Virus (HSV) Antibody IFA and Rubella IgG and IgM Antibody, EIA.
0248 - RICKETTSIAL DISEASE ANTIBODY PANEL, IFA:
This panel includes IgG and IgM specific titers against spotted fever group (Rickettsia rickettsia) and typhus group (Rickettsia typhi).
0251 - ROCKY MOUNTAIN SPOTTED FEVER GROUP (RICKETTSIAL) ANTIBODY, IFA:
Antigen specific IgG and IgM titers allow rapid diagnosis of infection by any of the spotted fever group of rickettsial agents. This group of agents include R. rickettsia (Rocky Mountain Spotted Fever) and R. acari (Rickettsial pox), both seen in the continental United States.
0255 - RPR (RAPID PLASMA REAGIN), SERUM:
The RPR test is a nontreponemal test to detect antibody reactive with lipoidal antigen of T. pallidum. Reactivity of the RPR test does not develop until 1-4 weeks after the appearance of the chancre. Nontreponemal tests are reactive in primary syphilis in 75-90% of cases, in secondary syphilis nearly 100% of cases are reactive with titers generally 16 and in untreated latent syphilis 70% of the cases are reactive. After adequate treatment of primary and secondary syphilis, there should be at least a four-fold decline in titer by 3 months. False positive RPR results occur in 1% to 2% of the normal population, after acute febrile illnesses, after immunizations or during pregnancy. Chronic false-positives are seen in autoimmune diseases (SLE), chronic infections and in IV drug users. Generally these titers are 8.
0257 - RUBELLA IgG AND IgM ANTIBODY PANEL, EIA, SERUM:
The detection of IgG antibodies suggests prior exposure to the virus, either natural or vaccine induced. The demonstration of IgM is valuable in detecting active or recent rubella infections.
0263 - ST LOUIS ENCEPHALITIS VIRUS ANTIBODY, IFA, SERUM:
Titers 16 are suggestive of exposure while the presence of IgM indicates recent infection. Human infections are seasonal, from mid to late summer, occurring throughout the southern, southwestern, and west central states. Strong cross reactivity may be seen with other Group B arboviruses (Flavivirus) including Dengue, Japanese Encephalitis, Rio Bravo, Powassan, and Yellow Fever.
0269 - TORCH PANEL, SERUM:
Panel includes: Cytomegalovirus IgG & IgM antibody, EIA; Herpes Simplex Virus (HSV) IgG & IgM, IFA; Rubella IgG & IgM antibody, EIA and Toxoplasmosis IgG and IgM antibody, EIA.
0274 - TYPHUS FEVER GROUP, RICKETTSIAL ANTIBODY PANEL, IFA:
Antigen-specific IgG and IgM titers allow rapid diagnosis of infection by one or more of the Typhus Fever Group of rickettsial agents. This group includes Rickettsia typhi (endemic or murine typhus), R. prowazekii (epidemic typhus), and Brill-Zinsser disease caused by reactivation of latent R. prowazekii.
0282 - WESTERN EQUINE ENCEPHALITIS IgG AND IgM ANTIBODY PANEL, IFA, SERUM:
Titers 16 are suggestive of exposure while the presence of IgM indicates recent infection. Human infections are seasonal, from mid to late summer, occurring throughout the western United States. Minimal cross reactivity exists with other Group A Arboviruses, i.e. Eastern Equine Encephalitis Virus.